To form 3D structures with composites of living cells and hydrogel is now becoming an attractive technology in both bioengineering and manufacturing areas. Variant processes have been presented, most of which are based on the cell composite extrusion and deposition technique. So, the design of cell extrusion nozzle turns into an important phase, and the rheological properties of cell-hydrogel composites act as a key parameter and must be well investigated. In this paper, an entrance pressure detection device and adaptor for small-diameter tips were developed. With the hypothesis of power law fluid type, the power law constant and coefficient were calculated. As derived from the experimental results, the cell-hydrogel composites (with the maximum cell concentration of ) show no difference from hydrogel materials in rheological properties. Based on these, the manufacturability of cell-hydrogel composites was discussed. Also, the cell viability, which is another important issue in cell assembly technology, was discussed. The peak percentage (97%) was achieved at the flow rate of . The extruding duration and the maximum shear stress loaded on cells were considered as two influence mechanisms.
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e-mail: linfeng@tsinghua.edu.cn
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April 2008
Research Papers
Rheological Properties of Cell-Hydrogel Composites Extruding Through Small-Diameter Tips
Jie Cheng,
Jie Cheng
Key Laboratory for Advanced Materials Processing Technology of Ministry of Education, Department of Mechanical Engineering,
Tsinghua University
, Beijing, 100084, P.R.C.
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Feng Lin,
Feng Lin
Key Laboratory for Advanced Materials Processing Technology of Ministry of Education, Department of Mechanical Engineering,
e-mail: linfeng@tsinghua.edu.cn
Tsinghua University
, Beijing, 100084, P.R.C.
Search for other works by this author on:
Haixia Liu,
Haixia Liu
Key Laboratory for Advanced Materials Processing Technology of Ministry of Education, Department of Mechanical Engineering,
Tsinghua University
, Beijing, 100084, P.R.C.
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Yongnian Yan,
Yongnian Yan
Key Laboratory for Advanced Materials Processing Technology of Ministry of Education, Department of Mechanical Engineering,
Tsinghua University
, Beijing, 100084, P.R.C.
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Xiaohong Wang,
Xiaohong Wang
Key Laboratory for Advanced Materials Processing Technology of Ministry of Education, Department of Mechanical Engineering,
Tsinghua University
, Beijing, 100084, P.R.C.
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Renji Zhang,
Renji Zhang
Key Laboratory for Advanced Materials Processing Technology of Ministry of Education, Department of Mechanical Engineering,
Tsinghua University
, Beijing, 100084, P.R.C.
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Zhuo Xiong
Zhuo Xiong
Key Laboratory for Advanced Materials Processing Technology of Ministry of Education, Department of Mechanical Engineering,
Tsinghua University
, Beijing, 100084, P.R.C.
Search for other works by this author on:
Jie Cheng
Key Laboratory for Advanced Materials Processing Technology of Ministry of Education, Department of Mechanical Engineering,
Tsinghua University
, Beijing, 100084, P.R.C.
Feng Lin
Key Laboratory for Advanced Materials Processing Technology of Ministry of Education, Department of Mechanical Engineering,
Tsinghua University
, Beijing, 100084, P.R.C.e-mail: linfeng@tsinghua.edu.cn
Haixia Liu
Key Laboratory for Advanced Materials Processing Technology of Ministry of Education, Department of Mechanical Engineering,
Tsinghua University
, Beijing, 100084, P.R.C.
Yongnian Yan
Key Laboratory for Advanced Materials Processing Technology of Ministry of Education, Department of Mechanical Engineering,
Tsinghua University
, Beijing, 100084, P.R.C.
Xiaohong Wang
Key Laboratory for Advanced Materials Processing Technology of Ministry of Education, Department of Mechanical Engineering,
Tsinghua University
, Beijing, 100084, P.R.C.
Renji Zhang
Key Laboratory for Advanced Materials Processing Technology of Ministry of Education, Department of Mechanical Engineering,
Tsinghua University
, Beijing, 100084, P.R.C.
Zhuo Xiong
Key Laboratory for Advanced Materials Processing Technology of Ministry of Education, Department of Mechanical Engineering,
Tsinghua University
, Beijing, 100084, P.R.C.J. Manuf. Sci. Eng. Apr 2008, 130(2): 021014 (5 pages)
Published Online: April 9, 2008
Article history
Received:
May 4, 2007
Revised:
January 4, 2008
Published:
April 9, 2008
Citation
Cheng, J., Lin, F., Liu, H., Yan, Y., Wang, X., Zhang, R., and Xiong, Z. (April 9, 2008). "Rheological Properties of Cell-Hydrogel Composites Extruding Through Small-Diameter Tips." ASME. J. Manuf. Sci. Eng. April 2008; 130(2): 021014. https://doi.org/10.1115/1.2896215
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