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Journal Articles

Mechanical Consequence of Induced Intervertebral Disc Degeneration in the SPARC-Null Mouse

Mitchel C. Whittal, Sara Molladavoodi, Derek P. Zwambag, Magali Millecamps, Laura S. Stone, Diane E. Gregory
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. February 2021, 143(2): 024501.
Paper No: BIO-20-1065
https://doi.org/10.1115/1.4047995
Published Online: October 8, 2020
...) is a protein that contributes to the functioning and maintenance of the extracellular matrix. SPARC-null mice display accelerated IVD degeneration and pain-associated behaviors. This study examined if SPARC-null mice also display altered spine mechanics as compared to wild-type (WT) mice. Lumbar spines from...
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Topics: Intervertebral discs, Lumbar spine, Stiffness, Mechanical testing, Proteins, Mechanical properties
Journal Articles

Reduced Amount or Integrity of Arterial Elastic Fibers Alters Allometric Scaling Relationships for Aortic Diameter and Heart Weight, But Not Cardiac Function in Maturing Mice

Jessica E. Wagenseil
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. April 2019, 141(4): 044504.
Paper No: BIO-18-1348
https://doi.org/10.1115/1.4042766
Published Online: February 25, 2019
...Jessica E. Wagenseil Allometric scaling laws relate physiologic parameters to body weight. Genetically modified mice allow investigation of allometric scaling laws when fundamental cardiovascular components are altered. Elastin haploinsufficient (Eln +/− ) mice have reduced elastin amounts...
View Article titled, Reduced Amount or Integrity of Arterial Elastic Fibers Alters Allometric Scaling Relationships for Aortic Diameter and Heart Weight, But Not Cardiac Function in Maturing <span class="search-highlight">Mice</span>
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Topics: Cardiovascular system, Fibers, Scaling laws (Mathematical physics), Weight (Mass), Echocardiography, Physiology