... was developed to investigate cell-matrix interactions under unconfined compression conditions, using a tissue engineered encapsulating hydrogel seeded with chondrocytes. Model predictions of stress and strain distributions within the cell and on the cell boundary were shown to exhibit space-dependent responses...

... of an unconfined compression test of agarose hydrogel. A recent example from the area of cartilage research has been modeled, and the mechanical response was compared with cell viability. All examples showed good agreement between numerical and analytical/experimental results. In the current version of MSC...

... scaffold applications, hydrogel scaffolds have been utilized in tissue engineering as a technique to confide the desired proliferation of seeded cells in vitro and in vivo into its architecturally porous three-dimensional structures. Such fabrication techniques not only enable the reconstruction...

..., including biological tissues and hydrogels, to low-frequency forces. Combining the results of confined and unconfined compression experiments on gelatin hydrogels with finite element analysis (FEA) simulations of the experiments, we explore the role of polymer structure, loading, and boundary conditions...

...Uday Chippada; Bernard Yurke; Penelope C. Georges; Noshir A. Langrana Soft hydrogels serving as substrates for cell attachment are used to culture many types of cells. The mechanical properties of these gels influence cell morphology, growth, and differentiation. For studies of cell growth...