... altered stiffness, viscosity, ECM architecture, and curvature can start a vicious cycle that deviates farther and farther from the norm over time. For example, the stiffening of the tumor micro-environment activates the mechanosignaling pathways in cancer cells to deposit more collagen or secrete ECM...

...Simona Celi; Francesca Di Puccio; Paola Forte Among the available tools for the early diagnosis of breast cancer, the elastographic technique based on ultrasounds has many advantages such as the noninvasive measure, the absence of ionizing effects, the high tolerability by patients, and the wide...

... writing of human colon cancer cells (HT-29). The proposed four layers include a quartz disk, a sacrificial and adhesive layer, a metallic foil, and a cell suspension layer. The bubble formation-induced stress wave is responsible for droplet formation. It is found that the proposed metallic foil-assisted...

...Sangjo Shim; Man Geun Kim; Kyoungwoo Jo; Yong Seok Kang; Boreum Lee; Sung Yang; Sang-Mo Shin; Jong-Hyun Lee In this paper, frequency response (dynamic compression and recovery) is suggested as a new physical marker to differentiate between breast cancer cells (MCF7) and normal cells (MCF10A...

...Alptekin Aksan, Ph.D.; Allison Hubel, Ph.D.; John Bischof, Ph.D. 28 07 2009 biomembrane transport biothermics cancer molecular biophysics nanotechnology patient treatment proteins tumours Important applications of bioheat and mass transfer include biopreservation...

... of selection, timing, dose and delivery of these adjuvants are then elaborated. Finally, work with a particularly promising vascular adjuvant, TNF-alpha, that shows the ability to destroy all cancer within a cryosurgical iceball is highlighted. The earlier efforts of using chemotherapeutics with cryosurgery...

... experienced a high electrical field, the axon of the nerve, the interior of the blood vessel, and the ducts experienced no electrical field. This indicates that blood vessels, nerves, and lactiferous ducts adjacent to a tumor treated with electroporation will survive, while the cancerous lesion is ablated...

...Emily S. Day; Jennifer G. Morton; Jennifer L. West Advances in nanotechnology are enabling many new diagnostic and therapeutic approaches in cancer. In this review, examples where nanoparticles are employed to induce localized heating within tumors are explored. Approaches to nanoparticle-mediated...

...Devin McCormack; Mays Al-Shaer; Benjamin S. Goldschmidt; Paul S. Dale; Carolyn Henry; Chris Papageorgio; Kiran Bhattacharyya; John A. Viator Melanoma is the deadliest form of skin cancer and has the fastest growth rate of all cancer types. Proper staging of melanoma is required for clinical...

...Ka Yaw Teo; Bumsoo Han The efficacy of chemotherapy is significantly impaired by the multidrug resistance (MDR) of cancer cells. The mechanism of MDR is associated with the overexpression of certain adenosine triphosphate-binding cassette protein transporters in plasma membranes, which actively...

... With Radiation and Chemotherapy ,” Cancer Res. 0008-5472 , 44 , pp. 4714s – 4720s . Dewey , W. C. , and Freeman , M. L. , 1980 , “ Rationale for Use of Hyperthermia in Cancer Therapy ,” Ann. N. Y. Acad. Sci. , 335 , pp. 372 – 378 . 10.1111/j.1749-6632.1980.tb50762.x 0077-8923...

...Yusheng Feng; J. Tinsley Oden; Marissa Nichole Rylander The ultimate goal of cancer treatment utilizing thermotherapy is to eradicate tumors and minimize damage to surrounding host tissues. To achieve this goal, it is important to develop an accurate cell damage model to characterize the population...

... 2006 radiation therapy biological organs hyperthermia cancer tumours numerical analysis bioheat transfer phase change benign prostate hyperplasia (BPH) transurethral microwave thermotherapy (TUMT) multi-organ simulation prostate This paper sets forth a novel use...

...Zuoping Li; Neha B. Butala; Brandon S. Etheridge; Herrick J. Siegel; Jack E. Lemons; Alan W. Eberhardt Periacetabular bone metastases cause severe pain and functional disability in cancer patients. Percutaneous acetabuloplasty (PCA) is a minimally invasive, image-guided procedure whereby cement...

...Manu Mital; E. P. Scott Breast cancer is the most common cancer among women. Thermography, also known as thermal or infrared imaging, is a procedure to determine if an abnormality is present in the breast tissue temperature distribution. This abnormality in temperature distribution might indicate...

.... Lowering of the cooling rate decreases the excision force even if the temperature of the liver remains unchanged. The lower the temperature of the liver is, the larger the increment rate of excision force is with regard to the cooling rate. Since many liver cancer patients have cirrhosis...

...F. Scott Gayzik; Elaine P. Scott; Tahar Loulou Hyperthermia is a cancer treatment modality in which body tissue is exposed to elevated temperatures to destroy cancerous cells. Hyperthermia treatment planning refers to the use of computational models to optimize the heating protocol with the goal...

... patient treatment blood vessels vaporisation drops bubbles tumours cancer numerical analysis ( a ) Pressure and ( b ) shear stress on the tube wall at various times for case 3 in Table 1 , Re = 427.59 , We = 6.93 , St = 10.47 , Ω s = 5 × 10 − 9...

... biophysics adhesion tumours cancer haemorheology computational fluid dynamics capillarity hydrodynamics shear stress cell deformability cell adhesion in vitro flow assay Cell adhesion to the microvascular endothelium is one of the important initial steps in the extravasation...

...Tao Ye; Joseph L. Bull We are currently developing a novel gas embolotherapy technique that involves the selective, acoustic vaporization of liquid perfluorocarbon droplets in or near a tumor as a possible treatment for cancer. The resulting bubbles can then stick within the tumor vasculature...