The role of trabeculae carneae in modulating left ventricular (LV) diastolic compliance remains unclear. The objective of this study was to determine the contribution of trabeculae carneae to the LV diastolic compliance. LV pressure–volume compliance curves were measured in six human heart explants from patients with LV hypertrophy at baseline and following trabecular cutting. The effect of trabecular cutting was also analyzed with finite-element model (FEM) simulations. Our results demonstrated that LV compliance improved after trabecular cutting (p < 0.001). Finite-element simulations further demonstrated that stiffer trabeculae reduce LV compliance further, and that the presence of trabeculae reduced the wall stress in the apex. In conclusion, we demonstrate that integrity of the LV and trabeculae is important to maintain LV stiffness and loss in trabeculae leads to more LV compliance.
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March 2017
Research-Article
The Effect of Trabeculae Carneae on Left Ventricular Diastolic Compliance: Improvement in Compliance With Trabecular Cutting
David L. Halaney,
David L. Halaney
Department of Medicine,
The University of Texas Health Science
Center at San Antonio,
San Antonio, TX 78229;
The University of Texas Health Science
Center at San Antonio,
San Antonio, TX 78229;
Department of Veterans Affairs,
South Texas Veterans Health Care System,
San Antonio, TX 78229
South Texas Veterans Health Care System,
San Antonio, TX 78229
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Arnav Sanyal,
Arnav Sanyal
Department of Mechanical Engineering,
University of Texas at San Antonio,
San Antonio, TX 78249
University of Texas at San Antonio,
San Antonio, TX 78249
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Navid A. Nafissi,
Navid A. Nafissi
Department of Medicine,
The University of Texas Health Science
Center at San Antonio,
San Antonio, TX 78229
The University of Texas Health Science
Center at San Antonio,
San Antonio, TX 78229
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Daniel Escobedo,
Daniel Escobedo
Department of Medicine,
The University of Texas Health Science
Center at San Antonio,
San Antonio, TX 78229;
The University of Texas Health Science
Center at San Antonio,
San Antonio, TX 78229;
Department of Veterans Affairs,
South Texas Veterans Health Care System,
San Antonio, TX 78229
South Texas Veterans Health Care System,
San Antonio, TX 78229
Search for other works by this author on:
Martin Goros,
Martin Goros
Department of Epidemiology and Biostatistics,
The University of Texas Health Science
Center at San Antonio,
San Antonio, TX 78229
The University of Texas Health Science
Center at San Antonio,
San Antonio, TX 78229
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Joel Michalek,
Joel Michalek
Department of Epidemiology and Biostatistics,
The University of Texas Health Science
Center at San Antonio,
San Antonio, TX 78229
The University of Texas Health Science
Center at San Antonio,
San Antonio, TX 78229
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Pedro J. Acevedo,
Pedro J. Acevedo
Department of Anatomy,
University of Environmental
and Applied Sciences U.D.C.A.,
Bogotá, Cundinamarca, Colombia
University of Environmental
and Applied Sciences U.D.C.A.,
Bogotá, Cundinamarca, Colombia
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William Pérez,
William Pérez
Department of Anatomy,
Faculty of Veterinary Medicine,
University of the Republic,
Montevideo 11200, Uruguay
Faculty of Veterinary Medicine,
University of the Republic,
Montevideo 11200, Uruguay
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G. Patricia Escobar,
G. Patricia Escobar
Department of Medicine,
The University of Texas Health Science
Center at San Antonio,
San Antonio, TX 78229
The University of Texas Health Science
Center at San Antonio,
San Antonio, TX 78229
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Marc D. Feldman,
Marc D. Feldman
Department of Medicine,
The University of Texas Health Science
Center at San Antonio,
San Antonio, TX 78229;
The University of Texas Health Science
Center at San Antonio,
San Antonio, TX 78229;
Department of Veterans Affairs,
South Texas Veterans Health Care System,
San Antonio, TX 78229
e-mail: feldmanm@uthscsa.edu
South Texas Veterans Health Care System,
San Antonio, TX 78229
e-mail: feldmanm@uthscsa.edu
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Hai-Chao Han
Hai-Chao Han
Fellow ASME
Department of Mechanical Engineering,
University of Texas at San Antonio,
San Antonio, TX 78249
Department of Mechanical Engineering,
University of Texas at San Antonio,
San Antonio, TX 78249
Search for other works by this author on:
David L. Halaney
Department of Medicine,
The University of Texas Health Science
Center at San Antonio,
San Antonio, TX 78229;
The University of Texas Health Science
Center at San Antonio,
San Antonio, TX 78229;
Department of Veterans Affairs,
South Texas Veterans Health Care System,
San Antonio, TX 78229
South Texas Veterans Health Care System,
San Antonio, TX 78229
Arnav Sanyal
Department of Mechanical Engineering,
University of Texas at San Antonio,
San Antonio, TX 78249
University of Texas at San Antonio,
San Antonio, TX 78249
Navid A. Nafissi
Department of Medicine,
The University of Texas Health Science
Center at San Antonio,
San Antonio, TX 78229
The University of Texas Health Science
Center at San Antonio,
San Antonio, TX 78229
Daniel Escobedo
Department of Medicine,
The University of Texas Health Science
Center at San Antonio,
San Antonio, TX 78229;
The University of Texas Health Science
Center at San Antonio,
San Antonio, TX 78229;
Department of Veterans Affairs,
South Texas Veterans Health Care System,
San Antonio, TX 78229
South Texas Veterans Health Care System,
San Antonio, TX 78229
Martin Goros
Department of Epidemiology and Biostatistics,
The University of Texas Health Science
Center at San Antonio,
San Antonio, TX 78229
The University of Texas Health Science
Center at San Antonio,
San Antonio, TX 78229
Joel Michalek
Department of Epidemiology and Biostatistics,
The University of Texas Health Science
Center at San Antonio,
San Antonio, TX 78229
The University of Texas Health Science
Center at San Antonio,
San Antonio, TX 78229
Pedro J. Acevedo
Department of Anatomy,
University of Environmental
and Applied Sciences U.D.C.A.,
Bogotá, Cundinamarca, Colombia
University of Environmental
and Applied Sciences U.D.C.A.,
Bogotá, Cundinamarca, Colombia
William Pérez
Department of Anatomy,
Faculty of Veterinary Medicine,
University of the Republic,
Montevideo 11200, Uruguay
Faculty of Veterinary Medicine,
University of the Republic,
Montevideo 11200, Uruguay
G. Patricia Escobar
Department of Medicine,
The University of Texas Health Science
Center at San Antonio,
San Antonio, TX 78229
The University of Texas Health Science
Center at San Antonio,
San Antonio, TX 78229
Marc D. Feldman
Department of Medicine,
The University of Texas Health Science
Center at San Antonio,
San Antonio, TX 78229;
The University of Texas Health Science
Center at San Antonio,
San Antonio, TX 78229;
Department of Veterans Affairs,
South Texas Veterans Health Care System,
San Antonio, TX 78229
e-mail: feldmanm@uthscsa.edu
South Texas Veterans Health Care System,
San Antonio, TX 78229
e-mail: feldmanm@uthscsa.edu
Hai-Chao Han
Fellow ASME
Department of Mechanical Engineering,
University of Texas at San Antonio,
San Antonio, TX 78249
Department of Mechanical Engineering,
University of Texas at San Antonio,
San Antonio, TX 78249
1Corresponding author.
Manuscript received May 25, 2016; final manuscript received December 13, 2016; published online January 24, 2017. Assoc. Editor: Thao (Vicky) Nguyen.
J Biomech Eng. Mar 2017, 139(3): 031012 (8 pages)
Published Online: January 24, 2017
Article history
Received:
May 25, 2016
Revised:
December 13, 2016
Citation
Halaney, D. L., Sanyal, A., Nafissi, N. A., Escobedo, D., Goros, M., Michalek, J., Acevedo, P. J., Pérez, W., Patricia Escobar, G., Feldman, M. D., and Han, H. (January 24, 2017). "The Effect of Trabeculae Carneae on Left Ventricular Diastolic Compliance: Improvement in Compliance With Trabecular Cutting." ASME. J Biomech Eng. March 2017; 139(3): 031012. https://doi.org/10.1115/1.4035585
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