Murine models of disease are a powerful tool for researchers to gain insight into disease formation, progression, and therapies. The biomechanical indicators of diseased tissue provide a unique insight into some of these murine models, since the biomechanical properties in scenarios such as aneurysm and Marfan syndrome can dictate tissue failure and mortality. Understanding the properties of the tissue on the macroscopic scale has been shown to be important, as one can then understand the tissue’s ability to withstand the high stresses seen in the cardiac pulsatile cycle. Alterations in the biomechanical response can foreshadow prospective mechanical failure of the tissue. These alterations are often seen on the microstructural level, and obtaining detailed information on such changes can offer a better understanding of the phenomena seen on the macroscopic level. Unfortunately, mouse models present problems due to the size and delicate features in the mechanical testing of such tissues. In addition, some smaller arteries in large-animal studies (e.g., coronary and cerebral arteries) can present the same issues, and are sometimes unsuitable for planar biaxial testing. The purpose of this paper is to present a robust method for the investigation of the mechanical properties of small arteries and the classification of the microstructural orientation and degree of fiber alignment. This occurs through the cost-efficient modification of a planar biaxial tester that works in conjunction with a two-photon nonlinear microscope. This system provides a means to further investigate how microstructure and mechanical properties are modified in diseased transgenic animals where the tissue is in small tube form. Several other hard-to-test tubular specimens such as cerebral aneurysm arteries and atherosclerotic coronary arteries can also be tested using the described modular device.
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e-mail: jpv1@email.arizona.edu
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July 2011
Design Innovations
Adaptation of a Planar Microbiaxial Optomechanical Device for the Tubular Biaxial Microstructural and Macroscopic Characterization of Small Vascular Tissues
Joseph T. Keyes,
Joseph T. Keyes
Graduate Interdisciplinary Program in Biomedical Engineering,
The University of Arizona,
Tucson, AZ 85721
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Darren G. Haskett,
Darren G. Haskett
Graduate Interdisciplinary Program in Biomedical Engineering,
The University of Arizona,
Tucson, AZ 85721
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Urs Utzinger,
Urs Utzinger
Graduate Interdisciplinary Program in Biomedical Engineering, BIO5 Institute for Biocollaborative Research, Department of Biomedical Engineering,
The University of Arizona
, Tucson, AZ 85721
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Mohamad Azhar,
Mohamad Azhar
BIO5 Institute for Biocollaborative Research, Department of Cell Biology and Anatomy,
The University of Arizona
, Tucson, AZ 85721
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Jonathan P. Vande Geest
Jonathan P. Vande Geest
Graduate Interdisciplinary Program in Biomedical Engineering, The Department of Aerospace and Mechanical Engineering, BIO5 Institute for Biocollaborative Research, Department of Biomedical Engineering,
e-mail: jpv1@email.arizona.edu
The University of Arizona
, Tucson, AZ 85721
Search for other works by this author on:
Joseph T. Keyes
Graduate Interdisciplinary Program in Biomedical Engineering,
The University of Arizona,
Tucson, AZ 85721
Darren G. Haskett
Graduate Interdisciplinary Program in Biomedical Engineering,
The University of Arizona,
Tucson, AZ 85721
Urs Utzinger
Graduate Interdisciplinary Program in Biomedical Engineering, BIO5 Institute for Biocollaborative Research, Department of Biomedical Engineering,
The University of Arizona
, Tucson, AZ 85721
Mohamad Azhar
BIO5 Institute for Biocollaborative Research, Department of Cell Biology and Anatomy,
The University of Arizona
, Tucson, AZ 85721
Jonathan P. Vande Geest
Graduate Interdisciplinary Program in Biomedical Engineering, The Department of Aerospace and Mechanical Engineering, BIO5 Institute for Biocollaborative Research, Department of Biomedical Engineering,
The University of Arizona
, Tucson, AZ 85721e-mail: jpv1@email.arizona.edu
J Biomech Eng. Jul 2011, 133(7): 075001 (8 pages)
Published Online: July 29, 2011
Article history
Received:
March 1, 2011
Revised:
May 24, 2011
Posted:
June 30, 2011
Published:
July 29, 2011
Online:
July 29, 2011
Citation
Keyes, J. T., Haskett, D. G., Utzinger, U., Azhar, M., and Vande Geest, J. P. (July 29, 2011). "Adaptation of a Planar Microbiaxial Optomechanical Device for the Tubular Biaxial Microstructural and Macroscopic Characterization of Small Vascular Tissues." ASME. J Biomech Eng. July 2011; 133(7): 075001. https://doi.org/10.1115/1.4004495
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