A method is described for construction of an in vitro flow model based on in vivo measurements of the lumen geometry of the human carotid bifurcation. A large-scale physical model of the vessel lumen was constructed using fused deposition modeling (a rapid prototyping technique) based on magnetic resonance (MR) images of the carotid bifurcation acquired in a healthy volunteer. The lumen negative was then used to construct a flow model for experimental studies that examined the hemodynamic environment of subject-specific geometry and flow conditions. The physical model also supplements physician insight into the three-dimensional geometry of the arterial segment, complementing the two-dimensional images obtained by MR. Study of the specific geometry and flow conditions in patients with vascular disease may contribute to our understanding of the relationship between their hemodynamic environment and conditions that lead to the development and progression of arterial disease.
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August 2001
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Construction of a Physical Model of the Human Carotid Artery Based Upon In Vivo Magnetic Resonance Images
R. V. Yedavalli, Medical Student,
R. V. Yedavalli, Medical Student
College of Medicine, The University of Illinois at Chicago, Chicago, IL 60607
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F. Loth, Assistant Professor,
F. Loth, Assistant Professor
Department of Mechanical Engineering and Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607
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A. Yardimci, Senior Principal Engineer,
A. Yardimci, Senior Principal Engineer
Advanced Engineering Design Center, Baxter International, Round Lake, IL 60073
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W. F. Pritchard, Medical Officer,
W. F. Pritchard, Medical Officer
Food and Drug Administration, Rockville, MD 20852
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J. N. Oshinski, Associate Professor,
J. N. Oshinski, Associate Professor
Department of Radiology and Biomedical Engineering, Emory University, Atlanta, GA 30322
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L. Sadler, Chief Operating Officer, Adjunct Associate Professor,
L. Sadler, Chief Operating Officer, Adjunct Associate Professor
Visible Productions, Inc., Fort Collins, CO 80524
Department of Neurosurgey, University of Illinois at Chicago, Chicago, IL 60612
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F. Charbel, Associate Professor,
F. Charbel, Associate Professor
Department of Neurosurgery, University of Illinois at Chicago, Chicago, IL 60612
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N. Alperin, Associate Professor
N. Alperin, Associate Professor
Department of Radiology and Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60612
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R. V. Yedavalli, Medical Student
College of Medicine, The University of Illinois at Chicago, Chicago, IL 60607
F. Loth, Assistant Professor
Department of Mechanical Engineering and Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607
A. Yardimci, Senior Principal Engineer
Advanced Engineering Design Center, Baxter International, Round Lake, IL 60073
W. F. Pritchard, Medical Officer
Food and Drug Administration, Rockville, MD 20852
J. N. Oshinski, Associate Professor
Department of Radiology and Biomedical Engineering, Emory University, Atlanta, GA 30322
L. Sadler, Chief Operating Officer, Adjunct Associate Professor
Visible Productions, Inc., Fort Collins, CO 80524
Department of Neurosurgey, University of Illinois at Chicago, Chicago, IL 60612
F. Charbel, Associate Professor
Department of Neurosurgery, University of Illinois at Chicago, Chicago, IL 60612
N. Alperin, Associate Professor
Department of Radiology and Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60612
Contributed by the Bioengineering Division for publication in the JOURNAL OF BIOMECHANICAL ENGINEERING. Manuscript received by the Bioengineering Division May 11, 1999; revised manuscript received February 7, 2001. Associate Editor: C. R. Ethier.
J Biomech Eng. Aug 2001, 123(4): 372-376 (5 pages)
Published Online: May 11, 1999
Article history
Received:
May 11, 1999
Received:
February 7, 2001
Citation
Yedavalli , R. V., Loth , F., Yardimci, A., Pritchard , W. F., Oshinski , J. N., Sadler , L., Charbel , F., and Alperin , N. (May 11, 1999). "Construction of a Physical Model of the Human Carotid Artery Based Upon In Vivo Magnetic Resonance Images ." ASME. J Biomech Eng. August 2001; 123(4): 372–376. https://doi.org/10.1115/1.1385845
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