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Technical Brief

Numerical Simulations of Freezing Process by Embedding a Cryo-Probe Into Water and Biological Tissue

[+] Author and Article Information
Jianghua Ke

Hygea Medical Technology Co., Ltd.,
18 ZhongGuanCun DongLu, Haidian District,
Beijing 100083, China;
State Key Laboratory of Hydroscience and Engineering,
Department of Energy and Power Engineering,
Tsinghua University,
Beijing 100084, China
e-mail: kejianghua@mail.tsinghua.edu.cn

Jian Xiao, Meng Li

Hygea Medical Technology Co., Ltd.,
18 ZhongGuanCun DongLu, Haidian District,
Beijing 100083, China

1Corresponding author.

Manuscript received February 13, 2019; final manuscript received May 5, 2019; published online June 7, 2019. Assoc. Editor: Linxia Gu.

ASME J of Medical Diagnostics 2(3), 034501 (Jun 07, 2019) (8 pages) Paper No: JESMDT-19-1005; doi: 10.1115/1.4043702 History: Received February 13, 2019; Revised May 05, 2019

Numerical simulations by finite volume method were performed to investigate the freezing process and growing up of ice ball by embedding a cryo-probe either into a glass tank full of water or biological tissues with and without a tumor. For water tank cases, numerical results of ice-ball size and the temperature history of the ice ball during the freezing process are in good agreement with the experimental measurements as long as the convective heat coefficient is reasonably chosen. In biological tissue cases, numerical simulations performed based on various vascular models indicate the effects of the existence of large blood vessels are not negligible.

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References

Rubinsky, B. , 2000, “ Cryosurgery,” Annu. Rev. Biomed. Eng., 2, pp. 157–187. [CrossRef] [PubMed]
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Figures

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Fig. 1

Cryo-probe of the HYGEA KB Cryosurgical System

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Fig. 2

Configuration of freezing process in water tank case

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Fig. 3

Diameters of the ice balls during a freezing process

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Fig. 4

Comparison of numerical results of temperature history against experiments at the points of 5 mm, 10 mm, 15 mm, 20 mm from probe

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Fig. 5

Size of ice ball and temperature at different points after 5 min freezing

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Fig. 6

Size of ice ball and temperature at different points after 10 min freezing

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Fig. 7

Size of ice ball and temperature at different points after 20 min freezing

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Fig. 8

Size of ice ball and temperature at different points after 40 min freezing

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Fig. 9

Time history of volume of ice ball during freezing (a) and temperature recovery (b)

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Fig. 10

Sizes of ice ball (mm) at different time during a freezing process

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Fig. 11

Sizes of ice ball (mm) at different time during a temperature recovery process

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Fig. 12

Ice-ball sizes (mm) at different temperature range

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Fig. 13

Temperature profiles along the line perpendicular to large vessel on plane yz plane for (a) case 2: BHTE model and (b) case 3: SACT model during a freezing process

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Fig. 14

Temperature profiles along the line perpendicular to large vessel on plane yz plane for (a) case 2: BHTE model and (b) case 4: SATT model during a freezing process

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