Review Article

The Aftermath of Bronchoconstriction

[+] Author and Article Information
Michael O'Sullivan

Department of Environmental Health, Harvard T.H Chan School of Public Health

Bo Lan

Department of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, 1-G07, Boston, MA, 02115, Tel: 617-784-7719

1Corresponding author.

ASME doi:10.1115/1.4042318 History: Received October 11, 2018; Revised October 30, 2018


Asthma is characterized by chronic airway inflammation, airway remodeling and excessive constriction of the airway. Detailed investigation exploring inflammation and the role of immune cells has revealed a variety of possible mechanisms by which chronic inflammation drives asthma development. However, the underlying mechanisms of asthma pathogenesis still remain poorly understood. New evidence now suggests that mechanical stimuli that arise during bronchoconstriction may play a critical role in asthma development. In this article, we review the mechanical effect of bronchoconstriction and how these mechanical stresses contribute to airway remodeling independently of inflammation.

Copyright (c) 2018 by ASME
Your Session has timed out. Please sign back in to continue.





Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related Journal Articles
Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In